线粒体融合蛋白-1 (EC 3.6.5.-) (Fzo同源物) (跨膜GTPase MFN1)
线粒体融合蛋白-1 (EC 3.6.5.-) (Fzo同源物) (跨膜GTPase MFN1)
Q8IWA4功能描述
介导线粒体聚集和融合的线粒体外膜GTPase (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303)。膜聚集需要GTPase活性 (PubMed:27920125)。这可能涉及卷曲螺旋结构域的重大重排 (PubMed:27920125, PubMed:28114303)。线粒体是高度动态的细胞器，其形态由线粒体融合和分裂事件之间的平衡决定 (PubMed:12475957, PubMed:12759376)。过表达诱导线粒体网络的形成（体外）(PubMed:12759376)。具有较低的GTPase活性 (PubMed:27920125, PubMed:28114303)。 {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}。
组织特异性
Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
亚细胞定位
Mitochondrion outer membrane
关键词