METTL5 Q9NRN9

rRNA N(6)-腺苷甲基转移酶 METTL5 (EC 2.1.1.-) (甲基转移酶样蛋白 5)

蛋白质信息 (UniProt)

rRNA N(6)-腺苷甲基转移酶 METTL5 (EC 2.1.1.-) (甲基转移酶样蛋白 5)

Q9NRN9

功能描述

与TRMT112形成异源二聚体的催化亚基，特异性甲基化18S rRNA第1832位腺嘌呤的第6位 (PubMed:31328227, PubMed:32217665, PubMed:33357433, PubMed:33428944, PubMed:35033535)。18S rRNA中腺嘌呤(1832)的N6-甲基化位于18S rRNA的解码中心，是翻译、胚胎干细胞 (ESCs) 多能性和分化所必需的 (PubMed:33357433)。 {ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:32217665, ECO:0000269|PubMed:33357433, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:35033535}。

组织特异性

Expressed from very early development (8 post-conceptual weeks) and expression persists through adulthood in multiple substructures of the brain, including the cerebellar cortex, hippocampus, and striatum.

亚细胞定位

Nucleus

关键词

3D-structure Cell projection Intellectual disability Methyltransferase Nucleus Proteomics identification Reference proteome S-adenosyl-L-methionine Synapse Transferase

外部链接

UniProt: Q9NRN9

NCBI Gene

GeneCards