MEST Q5EB52

中胚层特异性转录本同源蛋白 (EC 3.-.-.-) (父系表达基因1蛋白)

功能描述

在大脑发育过程中，在使神经元从双极形态转变为多极形态方面发挥重要作用，这一过程对于它们向皮层板的正确迁移至关重要。该功能可能是通过调节N-钙黏蛋白依赖性细胞粘附以及调节Akt和经典Wnt信号通路来实现的。对于发育过程中中脑-间脑多巴胺能(mdDA)神经元的发育和维持至关重要。在成脂分化过程中，通过减少Wnt共受体LRP6的糖基化、成熟和细胞膜定位，负向调节经典Wnt信号通路。 {ECO:0000250|UniProtKB:Q07646}。

组织特异性

Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.

亚细胞定位

Endoplasmic reticulum membrane