MEPE Q9NQ76

细胞外基质磷糖蛋白 (成骨细胞/骨细胞因子45) (OF45) (骨调节素)

功能描述

促进肾脏磷酸盐排泄并抑制肠道磷酸盐吸收 (PubMed:14962809, PubMed:19005008)。通过成骨细胞促进骨矿化，通过软骨细胞促进软骨矿化 (PubMed:18162525, PubMed:19998030, PubMed:22766095)。调节颅面复合体（如牙齿、骨和软骨）细胞外基质的矿化 (By similarity)。促进牙髓干细胞增殖和分化 (PubMed:22341070)。 {ECO:0000250|UniProtKB:Q8K4L6, ECO:0000269|PubMed:14962809, ECO:0000269|PubMed:18162525, ECO:0000269|PubMed:19005008, ECO:0000269|PubMed:19998030, ECO:0000269|PubMed:22341070, ECO:0000269|PubMed:22766095}。

组织特异性

Detected in urine (at protein level) (PubMed:37453717). Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058). Expressed by stem cells in dental pulp (PubMed:15153459). Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070). Expressed in teeth, specifically in decidious dentin (PubMed:20581062). Expressed in ondotoblasts (PubMed:12489176). Expressed in salivary glands (PubMed:15329369). Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762).

亚细胞定位

Secreted, extracellular space, extracellular matrix