MEIS1 O00470

同源盒蛋白 Meis1

功能描述

作为PAX6的转录调节因子。与PBX1或PBX2形成复合物，作为PF4的转录激活因子。为造血、巨核细胞谱系发育和血管模式形成所必需。可能在诱导髓系白血病中作为HOXA7和HOXA9的辅因子。 {ECO:0000269|PubMed:12609849}。

组织特异性

Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

亚细胞定位

Nucleus