MAVS Q7Z434

线粒体抗病毒信号蛋白 (MAVS) (诱导干扰素β的CARD接头蛋白) (Cardif) (干扰素β启动子刺激蛋白1) (IPS-1) (推定NF-kappa-B激活蛋白031N) (病毒诱导信号接头蛋白) (VISA)

功能描述

针对病毒先天免疫防御所需的接头蛋白 (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970, PubMed:39589880). 作用于检测病毒复制过程中产生的细胞内dsRNA的DHX33、RIGI和IFIH1/MDA5下游，协调导致NF-kappa-B、IRF3和IRF7激活的通路，并随后诱导抗病毒细胞因子如IFNB和RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251, PubMed:40042308). 过氧化物酶体和线粒体MAVS依次作用以建立抗病毒细胞状态 (PubMed:20451243). 在病毒感染时，过氧化物酶体MAVS诱导干扰素非依赖性防御因子的快速表达，提供短期保护，而线粒体MAVS激活具有延迟动力学的干扰素依赖性信号通路，从而放大并稳定抗病毒反应 (PubMed:20451243). 可能在TLR3检测到细胞外dsRNA后激活相同的通路 (PubMed:16153868). 可能保护细胞免于凋亡 (PubMed:16125763). 通过介导NLRP3募集到线粒体参与NLRP3炎症小体的激活 (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970, ECO:0000269|PubMed:39589880, ECO:0000269|PubMed:40042308}.

组织特异性

Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

亚细胞定位

Mitochondrion outer membrane