E3泛素蛋白连接酶MARCHF1 (EC 2.3.2.27) (膜相关RING指蛋白1) (膜相关RING-CH蛋白I) (MARCH-I) (RING指蛋白171) (RING型E3泛素转移酶MARCHF1)
E3泛素蛋白连接酶MARCHF1 (EC 2.3.2.27) (膜相关RING指蛋白1) (膜相关RING-CH蛋白I) (MARCH-I) (RING指蛋白171) (RING型E3泛素转移酶MARCHF1)
Q8TCQ1功能描述
E3 ubiquitin-protein ligase，介导TFRC、CD86、FAS和MHC class II proteins（如HLA-DR alpha和beta）的泛素化，并通过多囊泡体促进其随后的内吞和分选至溶酶体 (PubMed:18389477, PubMed:18305173, PubMed:21220452, PubMed:35045264)。通过在未成熟树突状细胞中组成型泛素化MHC class II proteins，下调其细胞表面定位，从而将其隔离在细胞内内体系统中。还通过直接泛素化和降解来控制胰岛素受体亚基beta/INSR的表面表达，从而调节胰岛素敏感性 (PubMed:27577745)。 {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:21220452, ECO:0000269|PubMed:27577745, ECO:0000269|PubMed:35045264}。; FUNCTION: (Microbial infection) 在人巨细胞病毒感染期间通过调节转铁蛋白受体TFRC的水平在铁代谢中发挥作用，随后有助于产生促病毒效应。 {ECO:0000269|PubMed:35045264}。
组织特异性
Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
亚细胞定位
Golgi apparatus, trans-Golgi network membrane
关键词