MAPKBP1 O60336

丝裂原活化蛋白激酶结合蛋白1 (JNK结合蛋白1) (JNKBP-1)

功能描述

NOD2功能的负调控因子。它下调NOD2诱导的过程，如NF-kappa-B信号通路的激活、IL8分泌和抗菌反应 (PubMed:22700971)。参与JNK信号通路 (By similarity)。 {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}。

组织特异性

Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes (PubMed:22700971). Expressed in kidney (PubMed:28089251).

亚细胞定位

Cytoplasm