MAP激酶激活蛋白激酶5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38调节/激活蛋白激酶) (PRAK)
MAP激酶激活蛋白激酶5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38调节/激活蛋白激酶) (PRAK)
Q8IW41功能描述
肿瘤抑制因子serine/threonine-protein kinase，参与mTORC1信号传导和转录后调控。磷酸化FOXO3、ERK3/MAPK6、ERK4/MAPK4、HSP27/HSPB1、p53/TP53和RHEB。作为肿瘤抑制因子发挥作用，通过介导Ras诱导的衰老和磷酸化p53/TP53。参与MYC的转录后调控，通过介导FOXO3的磷酸化：FOXO3的磷酸化导致促进FOXO3的核定位，使得miR-34b和miR-34c得以表达，这两者是MYC的转录后调控因子，结合到MYC转录本的3'UTR并阻止MYC翻译。作为mTORC1信号传导的负调控因子发挥作用，通过介导RHEB的磷酸化和抑制。通过与ERK3/MAPK6或ERK4/MAPK4相互作用参与非典型MAPK信号传导：与ERK3/MAPK6或ERK4/MAPK4形成的复合物的确切作用尚不清楚，但该复合物经历了一系列复杂的磷酸化事件：在与非典型MAPK（ERK3/MAPK6或ERK4/MAPK4）相互作用后，ERK3/MAPK6（或ERK4/MAPK4）被磷酸化，随后介导MAPKAPK5的磷酸化和激活，后者反过来磷酸化ERK3/MAPK6（或ERK4/MAPK4）。响应PKA/PRKACA刺激介导HSP27/HSPB1的磷酸化，诱导F-actin重排。 {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.
组织特异性
Expressed ubiquitously.
亚细胞定位
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
关键词