MAP3K4 Q9Y6R4

丝裂原活化蛋白激酶激酶激酶4 (EC 2.7.11.25) (MAP三激酶1) (MAPK/ERK激酶激酶4) (MEK激酶4) (MEKK 4)

蛋白质信息 (UniProt)

丝裂原活化蛋白激酶激酶激酶4 (EC 2.7.11.25) (MAP三激酶1) (MAPK/ERK激酶激酶4) (MEK激酶4) (MEKK 4)

Q9Y6R4

功能描述

蛋白激酶信号转导级联反应的组分。激活CSBP2、P38和JNK MAPK通路，但不激活ERK通路。特异性磷酸化并激活MAP2K4和MAP2K6。{ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}。

组织特异性

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.

亚细胞定位

Cytoplasm, perinuclear region

关键词

Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q9Y6R4

NCBI Gene

GeneCards