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MAP2K3 P46734

双特异性丝裂原活化蛋白激酶激酶3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK激酶3) (MEK 3) (应激激活蛋白激酶激酶2) (SAPK激酶2) (SAPKK-2) (SAPKK2)

蛋白质信息 (UniProt)

双特异性丝裂原活化蛋白激酶激酶3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK激酶3) (MEK 3) (应激激活蛋白激酶激酶2) (SAPK激酶2) (SAPKK-2) (SAPKK2)

P46734

功能描述

双特异性激酶。在体内被细胞因子和环境应激激活。催化MAP激酶p38中苏氨酸和酪氨酸残基的伴随磷酸化。是始于肾上腺素受体ADRA1B激活并导致MAPK14激活的信号级联反应的一部分。{ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}。

组织特异性

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

关键词

Acetylation Alternative splicing ATP-binding Disease variant Kinase Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase

外部链接

UniProt: P46734
NCBI Gene