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MAP1LC3A Q9H492

微管相关蛋白1轻链3α (自噬相关蛋白LC3 A) (自噬相关泛素样修饰因子LC3 A) (MAP1轻链3样蛋白1) (微管相关蛋白1A/1B轻链3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B轻链3 A)

蛋白质信息 (UniProt)

微管相关蛋白1轻链3α (自噬相关蛋白LC3 A) (自噬相关泛素样修饰因子LC3 A) (MAP1轻链3样蛋白1) (微管相关蛋白1A/1B轻链3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B轻链3 A)

Q9H492

功能描述

参与自噬泡(自噬体)形成的类泛素修饰因子 (PubMed:20713600, PubMed:24290141)。LC3s参与吞噬泡膜的延伸,而GABARAP/GATE-16亚家族对于自噬体成熟的后期阶段至关重要 (PubMed:20713600)。通过与网状自噬受体TEX264相互作用,参与营养应激下内质网亚结构域重塑为自噬体,随后与溶酶体融合以进行内质网更新 (PubMed:31006537, PubMed:31006538)。 {ECO:0000269|PubMed:20713600, ECO:0000269|PubMed:24290141, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}。

组织特异性

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

亚细胞定位

Cytoplasmic vesicle, autophagosome membrane

关键词

3D-structure Alternative splicing Autophagy Cytoplasm Cytoplasmic vesicle Cytoskeleton Lipoprotein Membrane Microtubule Phosphoprotein