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MAML2 Q8IZL2

类主宰蛋白2 (Mam-2)

蛋白质信息 (UniProt)

类主宰蛋白2 (Mam-2)

Q8IZL2

功能描述

作为NOTCH proteins的转录共激活因子。已被证明能放大NOTCH诱导的HES1转录。比MAML1或MAML3更有效地增强NOTCH3和NOTCH4的激活。 {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}.

组织特异性

Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.

亚细胞定位

Nucleus speckle

关键词

Activator Chromosomal rearrangement Notch signaling pathway Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation

外部链接

UniProt: Q8IZL2
NCBI Gene