丝氨酸/苏氨酸蛋白激酶 MAK (EC 2.7.11.1) (雄性生殖细胞相关激酶)
丝氨酸/苏氨酸蛋白激酶 MAK (EC 2.7.11.1) (雄性生殖细胞相关激酶)
P20794功能描述
对纤毛长度的调节至关重要，且为光感受器的长期存活所必需 (By similarity)。以细胞周期依赖性方式磷酸化FZR1。在AR的转录共激活中发挥作用。可能在精子发生中发挥重要功能。可能在前列腺癌细胞的染色体稳定性中发挥作用。 {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}。
组织特异性
Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
亚细胞定位
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment
关键词