MAGEC2 Q9UBF1

黑色素瘤相关抗原C2 (癌/睾丸抗原10) (CT10) (肝细胞癌相关抗原587) (MAGE-C2抗原) (MAGE-E1抗原)

功能描述

推测可增强含RING型锌指结构的E3泛素-蛋白连接酶的泛素连接酶活性。在体外增强TRIM28的泛素连接酶活性，并在Ubl结合酶UBE2H存在下刺激p53/TP53泛素化，导致p53/TP53降解。推测通过在E3:底物复合物处招募和/或稳定Ubl结合酶(E2)起作用。 {ECO:0000269|PubMed:20864041}。

组织特异性

Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is an inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression.

亚细胞定位

Cytoplasm