黑色素瘤相关抗原6 (癌/睾丸抗原1.6) (CT1.6) (MAGE-6抗原) (MAGE3B抗原)
黑色素瘤相关抗原6 (癌/睾丸抗原1.6) (CT1.6) (MAGE-6抗原) (MAGE3B抗原)
P43360功能描述
RING型锌指包含E3泛素-protein连接酶的泛素连接酶活性激活剂，作为自噬的抑制因子起作用 (PubMed:17942928, PubMed:20864041, PubMed:31267705)。可能增强TRIM28的泛素连接酶活性并刺激TRIM28对p53/TP53的泛素化。推测通过在E3:底物复合物处招募和/或稳定Ubl结合酶(E2)起作用 (PubMed:17942928, PubMed:20864041)。可能在肿瘤转化或肿瘤进展的某些方面发挥作用 (PubMed:17942928, PubMed:20864041)。体外实验中促进黑色素瘤细胞系的细胞存活 (PubMed:17942928)。 {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705}。
组织特异性
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
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