MADCAM1 Q13477

黏膜地址素细胞黏附分子-1 (MAdCAM-1) (hMAdCAM-1)

功能描述

由粘膜微静脉表达的细胞粘附白细胞受体，有助于引导淋巴细胞进入粘膜组织，包括Peyer斑和肠固有层。它既能结合整合素alpha-4/beta-7，也能结合L-selectin，调节白细胞的通过和滞留。缺乏粘蛋白样结构域的Isoform 2可能专用于支持整合素alpha-4/beta-7依赖性的粘附增强，且不依赖于L-selectin结合。

组织特异性

Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.

亚细胞定位

Membrane; Single-pass type I membrane protein.