LZTS1 Q9Y250

亮氨酸拉链假定肿瘤抑制因子1 (F37/食管癌相关基因编码亮氨酸拉链基序) (Fez1)

功能描述

参与细胞生长的调节。可能稳定活性的CDC2-cyclin B1复合物，从而有助于细胞周期的调节和防止不受控制的细胞增殖。可能作为肿瘤抑制因子发挥作用。 {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.

组织特异性

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.

亚细胞定位

Cytoplasm