富含亮氨酸重复序列蛋白 26 (BK通道辅助γ亚基LRRC26) (癌症中细胞角蛋白相关蛋白)
富含亮氨酸重复序列蛋白 26 (BK通道辅助γ亚基LRRC26) (癌症中细胞角蛋白相关蛋白)
Q2I0M4功能描述
大电导电压和钙激活钾通道(BK alpha)的辅助蛋白。在非兴奋细胞中，将BK alpha通道从高电压激活类型转换为低电压激活类型所必需的。其特征是负膜电压和持续的低钙水平。{ECO:0000269|PubMed:20613726, ECO:0000269|PubMed:22547800}。
组织特异性
Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels.
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