LRP6 O75581

低密度脂蛋白受体相关蛋白6 (LRP-6)

功能描述

Wnt-Fzd-LRP5-LRP6复合物的组分，通过诱导受体-配体复合物聚集成核糖体大小的信号体来触发beta-catenin信号传导 (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812, PubMed:34896607)。Wnt/beta-catenin信号传导的细胞表面共受体，在包括视网膜血管生成和骨形成在内的多种过程中起关键作用 (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812, PubMed:34896607)。Wnt诱导的Fzd/LRP6共受体复合物将DVL1聚合物募集到质膜，进而将AXIN1/GSK3B-复合物募集到细胞表面，促进信号体的形成并抑制AXIN1/GSK3介导的beta-catenin磷酸化和降解 (PubMed:16513652)。原肠胚形成过程中表皮后部模式形成所必需 (By similarity)。 {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812, ECO:0000269|PubMed:34896607}。

组织特异性

Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

亚细胞定位

Cell membrane