LPXN O60711

白细胞亲和素

功能描述

雄激素受体 (AR) 和血清反应因子 (SRF) 的转录共激活因子。参与调节细胞粘附、铺展和细胞迁移，并在整合素介导的细胞粘附事件中作为负调控因子。抑制整合素诱导的桩蛋白 (PXN) 酪氨酸磷酸化。可能在破骨细胞粘附区形成过程中作为接头蛋白发挥关键作用。负向调节B细胞抗原受体 (BCR) 信号传导。 {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}。

组织特异性

Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.

亚细胞定位

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region