LIPH Q8WWY8

脂肪酶成员H (LIPH) (EC 3.1.1.-) (LPD脂肪酶相关蛋白) (膜相关磷脂酸选择性磷脂酶A1-α) (mPA-PLA1 α) (磷脂酶A1成员B)

功能描述

特异性水解磷脂酸 (PA) 生成2-酰基溶血磷脂酸 (LPA; 一种强效生物活性脂质介质) 和脂肪酸。不水解其他磷脂，如磷脂酰丝氨酸 (PS)、磷脂酰胆碱 (PC) 和磷脂酰乙醇胺 (PE) 或三酰甘油 (TG)。 {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}。

组织特异性

Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In the skin, it is prominently expressed in hair follicles, including the stem cell-rich bulge region and the inner root sheath (PubMed:17095700, PubMed:32336749).

亚细胞定位

Secreted