LIMD1 Q9UGP4

含LIM域蛋白1

功能描述

作为适配蛋白或支架蛋白，参与多种蛋白复合物的组装，并参与多种细胞过程，如细胞命运决定、细胞骨架组织、基因转录抑制、细胞-细胞粘附、细胞分化、增殖和迁移。正向调节microRNA (miRNA)介导的基因沉默，对P-body的形成和完整性至关重要。作为缺氧调节因子，通过桥接脯氨酰羟化酶与VHL之间的关联，促进HIF1A的有效降解。作为转录共抑制因子，参与SNAI1和SNAI2/SLUG依赖性的E-cadherin转录抑制。负向调节Hippo信号通路并拮抗YAP1的磷酸化。抑制E2F介导的转录，并抑制大多数含有E2F1反应元件的基因的表达。调节成骨细胞的发育、功能、分化和应激性破骨细胞生成。增强TRAF6激活适配蛋白复合物1 (AP-1)的能力，并负向调节成骨细胞中经典的Wnt受体信号通路。可能通过抑制细胞增殖发挥抑癌因子作用。 {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.

组织特异性

Expressed in normal and breast cancer tissues (at protein level). Ubiquitous.

亚细胞定位

Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.