LIM结构域和肌动蛋白结合蛋白1 (肿瘤中丢失的上皮蛋白)
LIM结构域和肌动蛋白结合蛋白1 (肿瘤中丢失的上皮蛋白)
Q9UHB6功能描述
参与actin细胞骨架调节和动力学的actin结合蛋白。增加actin应力纤维的数量和大小，并抑制膜褶皱。抑制actin丝解聚。捆绑actin丝，延迟丝成核并减少分支丝的形成 (PubMed:12566430, PubMed:33999101)。作为初级纤毛形成的负调节因子 (PubMed:32496561)。在胆固醇稳态中发挥作用。通过调节肠道胆固醇吸收影响血浆胆固醇水平。可能作为支架蛋白发挥作用，通过招募MYO5B至NPC1L1来调节NPC1L1（一种胆固醇吸收所必需的蛋白）向细胞膜的转运，从而促进胆固醇摄取 (By similarity)。 {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}。
组织特异性
Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
亚细胞定位
Cytoplasm. Cell junction, focal adhesion
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