富含亮氨酸重复序列G蛋白偶联受体5 (G蛋白偶联受体49) (G蛋白偶联受体67) (G蛋白偶联受体HG38)
富含亮氨酸重复序列G蛋白偶联受体5 (G蛋白偶联受体49) (G蛋白偶联受体67) (G蛋白偶联受体HG38)
O75473功能描述
R-spondins的受体，增强典型Wnt信号通路，并作为肠上皮和毛囊的干细胞标志物。与R-spondins（RSPO1、RSPO2、RSPO3或RSPO4）结合后，与被细胞外Wnt受体激活的磷酸化LRP6和frizzled受体结合，触发典型Wnt信号通路以增加靶基因的表达。与经典的G蛋白偶联受体不同，不激活异源三聚体G蛋白来转导信号。参与胚后发育过程中成体肠干细胞的发育和/或维持。 {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.
组织特异性
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
亚细胞定位
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
关键词