半乳糖凝集素-1 (Gal-1) (14 kDa 层粘连蛋白结合蛋白) (HLBP14) (14 kDa 凝集素) (β-半乳糖苷结合凝集素 L-14-I) (半乳糖凝集素) (HBL) (HPL) (乳糖结合凝集素 1) (可溶性半乳糖苷结合凝集素 1) (推定 MAPK 激活蛋白 PM12) (S-Lac 凝集素 1)
半乳糖凝集素-1 (Gal-1) (14 kDa 层粘连蛋白结合蛋白) (HLBP14) (14 kDa 凝集素) (β-半乳糖苷结合凝集素 L-14-I) (半乳糖凝集素) (HBL) (HPL) (乳糖结合凝集素 1) (可溶性半乳糖苷结合凝集素 1) (推定 MAPK 激活蛋白 PM12) (S-Lac 凝集素 1)
P09382功能描述
结合β-半乳糖苷和多种复杂碳水化合物的凝集素。在调节细胞凋亡、细胞增殖和细胞分化中发挥作用。抑制CD45蛋白磷酸酶活性，从而抑制Lyn激酶的去磷酸化。T细胞凋亡的强诱导剂。通过激活受体CD69在Th17细胞分化中发挥负向作用 (PubMed:24752896)。 {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:24945728}。
组织特异性
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
亚细胞定位
Secreted, extracellular space, extracellular matrix
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