LEPR P48357

瘦素受体 (LEP-R) (HuB219) (OB受体) (OB-R) (CD抗原 CD295)

功能描述

激素LEP/leptin的受体 (Probable) (PubMed:22405007)。配体结合后，通过激活不同的信号通路（如JAK2/STAT3和MAPK cascade/FOS）介导LEP的中枢和外周效应。在下丘脑中，LEP作为食欲调节因子，通过诱导厌食因子和抑制促食欲神经肽，导致食物摄入减少和能量消耗增加，还调节骨质量和下丘脑-垂体-肾上腺激素的分泌 (By similarity) (PubMed:9537324)。在外周，增加基础代谢，影响生殖功能，调节胰腺beta细胞功能和胰岛素分泌，促血管生成，并影响先天免疫和适应性免疫 (PubMed:12504075, PubMed:25060689, PubMed:8805376)。能量稳态和黑皮素产生的控制（刺激POMC并完全抑制AgRP转录）由STAT3信号介导，而不同的信号调节NPY以及生育、生长和葡萄糖稳态的控制。参与调节对低血糖的反向调节反应，通过抑制臂旁核神经元。对T淋巴细胞反应有特异性作用，差异调节naive和memory T细胞的增殖。Leptin增加Th1并抑制Th2细胞因子的产生 (By similarity)。 {ECO:0000250|UniProtKB:P48356, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:22405007, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8805376, ECO:0000269|PubMed:9537324, ECO:0000305|PubMed:25232147}.; FUNCTION: [Isoform A]: 可能跨血脑屏障转运LEP。结合LEP并介导LEP内吞。不诱导STAT3磷酸化及激活STAT3。 {ECO:0000250|UniProtKB:P48356}.; FUNCTION: [Isoform E]: 拮抗Isoform A和isoform B介导的LEP结合和内吞。 {ECO:0000250|UniProtKB:P48356}.

组织特异性

Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075).

亚细胞定位

Cell membrane