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LDLRAD3 Q86YD5

含低密度脂蛋白受体A结构域蛋白3 (LDLR class A domain-containing protein 3)

蛋白质信息 (UniProt)

含低密度脂蛋白受体A结构域蛋白3 (LDLR class A domain-containing protein 3)

Q86YD5

功能描述

可能影响APP加工,导致sAPP-alpha产生减少以及淀粉样P3肽产生增加。可能调节ITCH和NEDD4 E3连接酶活性及降解 (PubMed:26854353)。 {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (微生物感染) 作为委内瑞拉马脑炎病毒的受体。 {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}.

组织特异性

Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Host-virus interaction Lipoprotein Membrane Proteomics identification Receptor