LDAH Q9H6V9

脂滴相关水解酶 (EC 3.1.1.13) (脂滴相关丝氨酸水解酶) (hLDAH)

功能描述

可能是与脂滴相关的丝氨酸脂质水解酶 (By similarity)。具有较低的胆固醇酯酶活性 (By similarity)。似乎缺乏甘油三酯脂肪酶活性 (By similarity)。参与胆固醇和甘油三酯稳态；具有相反的效应，促进细胞甘油三酯积累和细胞胆固醇释放 (PubMed:24357060, PubMed:28578400)。在调节细胞脂质储存方面与PNPLA2/ATGL起拮抗作用 (PubMed:28578400)。可能通过刺激PNPLA2/ATGL泛素化和蛋白酶体降解间接调节甘油三酯积累 (PubMed:28578400)。促进微管依赖性脂滴融合 (PubMed:28578400)。在动脉粥样硬化病变的巨噬细胞丰富区域高表达，提示其可能促进巨噬细胞中的胆固醇酯更新 (By similarity)。 {ECO:0000250|UniProtKB:Q8BVA5, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}。

组织特异性

Present in macrophage-rich areas in atherosclerotic lesions (at protein level) (PubMed:24357060). Expressed in monocytes and monocyte-derived macrophages (at protein level) (PubMed:24357060).

亚细胞定位

Lipid droplet