中性粒细胞明胶酶相关脂质运载蛋白 (NGAL) (25 kDa alpha-2-微球蛋白相关的MMP-9亚基) (脂质运载蛋白-2) (癌基因 24p3) (铁载体脂质运载蛋白) (p25)
中性粒细胞明胶酶相关脂质运载蛋白 (NGAL) (25 kDa alpha-2-微球蛋白相关的MMP-9亚基) (脂质运载蛋白-2) (癌基因 24p3) (铁载体脂质运载蛋白) (p25)
P80188功能描述
参与多种过程（如细胞凋亡、先天免疫和肾脏发育）的铁转运蛋白 (PubMed:12453413, PubMed:20581821, PubMed:27780864)。通过与2,3-二羟基苯甲酸 (2,3-DHBA) 结合来结合铁，2,3-DHBA是一种与细菌肠杆菌素结构相似的铁载体，根据具体情况向细胞递送或移除铁。结合铁的形式 (holo-24p3) 在结合SLC22A17 (24p3R) 受体后被内化，导致铁释放并随后增加细胞内铁浓度。相反，无铁形式 (apo-24p3) 与SLC22A17 (24p3R) 受体结合后，随后与细胞内铁载体结合，螯合铁并将铁转移至细胞外介质，从而降低细胞内铁浓度。参与由白细胞介素-3 (IL3) 缺乏引起的细胞凋亡：载铁形式增加细胞内铁浓度但不促进细胞凋亡，而无铁形式降低细胞内铁水平，诱导促凋亡蛋白BCL2L11/BIM的表达，导致细胞凋亡 (By similarity)。参与先天免疫；通过隔离结合微生物铁载体（如肠杆菌素）的铁来限制细菌增殖 (PubMed:27780864)。也能结合来自结核分枝杆菌 (M.tuberculosis) 的铁载体 (PubMed:15642259, PubMed:21978368)。 {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:15642259, ECO:0000269|PubMed:20581821, ECO:0000269|PubMed:21978368, ECO:0000269|PubMed:27780864}。
组织特异性
Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism (PubMed:9339356). High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung (PubMed:9339356). Expressed in the medullary tubules of the kidney (PubMed:30418175). Not found in the small intestine or peripheral blood leukocytes (PubMed:9339356).
亚细胞定位
Secreted
关键词