LAMTOR5 O43504

Ragulator复合体蛋白LAMTOR5 (乙型肝炎病毒X相互作用蛋白) (HBV X相互作用蛋白) (HBX相互作用蛋白) (晚期内体/溶酶体接头蛋白及MAPK和MTOR激活因子5)

功能描述

作为Ragulator复合体的一部分，它参与氨基酸感应和mTORC1的激活，mTORC1是一个响应生长因子、能量水平和氨基酸促进细胞生长的信号复合体 (PubMed:22980980, PubMed:29158492, PubMed:30181260)。通过涉及溶酶体V-ATPase的机制被氨基酸激活，Ragulator对小GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC和/或RagD/RRAGD)发挥双重作用：它(1)作为鸟嘌呤核苷酸交换因子(GEF)，激活小GTPases Rag，以及(2)介导Rag GTPases募集至溶酶体膜 (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260)。激活的Ragulator和Rag GTPases作为支架将mTORC1募集至溶酶体，并在那里被依次激活 (PubMed:22980980, PubMed:29158492, PubMed:30181260)。当与BIRC5形成复合物时，干扰凋亡体组装，阻止pro-caspase-9募集至寡聚化的APAF1，从而选择性抑制经由线粒体/细胞色素c途径启动的细胞凋亡 (PubMed:12773388)。 {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}。

组织特异性

Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung (PubMed:9499022). Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection (PubMed:9499022).

亚细胞定位

Lysosome