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LAMC2 Q13753

层粘连蛋白亚基γ-2 (细胞散射因子140 kDa亚基) (CSF 140 kDa亚基) (Epiligrin亚基γ) (Kalinin亚基γ) (Kalinin/nicein/epiligrin 100 kDa亚基) (Ladsin 140 kDa亚基) (层粘连蛋白B2t链) (层粘连蛋白-5亚基γ) (大粘附散射因子140 kDa亚基) (Nicein亚基γ)

蛋白质信息 (UniProt)

层粘连蛋白亚基γ-2 (细胞散射因子140 kDa亚基) (CSF 140 kDa亚基) (Epiligrin亚基γ) (Kalinin亚基γ) (Kalinin/nicein/epiligrin 100 kDa亚基) (Ladsin 140 kDa亚基) (层粘连蛋白B2t链) (层粘连蛋白-5亚基γ) (大粘附散射因子140 kDa亚基) (Nicein亚基γ)

Q13753

功能描述

通过高亲和力受体与细胞结合,laminin被认为通过与其他细胞外基质成分相互作用,在胚胎发育过程中介导细胞附着、迁移和组织进入组织。Ladsin对多种细胞发挥细胞散射活性,包括上皮细胞、内皮细胞和成纤维细胞。 {ECO:0000269|PubMed:8265624}。

组织特异性

The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.

亚细胞定位

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

关键词

Alternative splicing Basement membrane Cell adhesion Coiled coil Direct protein sequencing Disulfide bond Epidermolysis bullosa Extracellular matrix Glycoprotein Heparin-binding