层粘连蛋白亚基α-5 (层粘连蛋白-10亚基α) (层粘连蛋白-11亚基α) (层粘连蛋白-15亚基α)
层粘连蛋白亚基α-5 (层粘连蛋白-10亚基α) (层粘连蛋白-11亚基α) (层粘连蛋白-15亚基α)
O15230功能描述
通过高亲和力受体与细胞结合,laminin被认为通过与其他细胞外基质成分相互作用,在胚胎发育过程中介导细胞附着、迁移和组织进入组织。通过涉及整合素介导的信号传导和PTK2B/PYK2的机制,在骨骼发生调节中发挥作用 (PubMed:33242826)。 {ECO:0000269|PubMed:33242826}。
组织特异性
Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver. Expressed in muscle, ligaments, periosteum, trabecular bone and throughout the cartilage, particularly in the growth plate and in articular chondrocytes (PubMed:33242826).
亚细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
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