层粘连蛋白亚基α-4 (Laminin-14亚基α) (Laminin-8亚基α) (Laminin-9亚基α)
层粘连蛋白亚基α-4 (Laminin-14亚基α) (Laminin-8亚基α) (Laminin-9亚基α)
Q16363功能描述
通过高亲和力受体与细胞结合，laminin被认为通过与其他细胞外基质成分相互作用，在胚胎发育过程中介导细胞附着、迁移和细胞组织成组织。
组织特异性
Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
亚细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane. Secreted
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