层粘连蛋白α3亚基 (Epiligrin 170 kDa亚基) (E170) (Epiligrin α亚基) (Kalinin α亚基) (层粘连蛋白-5 α亚基) (层粘连蛋白-6 α亚基) (层粘连蛋白-7 α亚基) (Nicein α亚基)
层粘连蛋白α3亚基 (Epiligrin 170 kDa亚基) (E170) (Epiligrin α亚基) (Kalinin α亚基) (层粘连蛋白-5 α亚基) (层粘连蛋白-6 α亚基) (层粘连蛋白-7 α亚基) (Nicein α亚基)
Q16787功能描述
通过高亲和力受体与细胞结合,laminin被认为通过与其他细胞外基质成分相互作用,在胚胎发育期间介导细胞附着、迁移和组织进入组织中;FUNCTION: Laminin-5被认为参与(1)通过灶性粘附中的整合素alpha-3/beta-1和半桥粒中的整合素alpha-6/beta-4进行的细胞粘附,(2)通过pp125-FAK和p80的酪氨酸磷酸化进行的信号转导,(3)角质形成细胞的分化。
组织特异性
Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.
亚细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
关键词