返回首页

LAMA3 Q16787

层粘连蛋白α3亚基 (Epiligrin 170 kDa亚基) (E170) (Epiligrin α亚基) (Kalinin α亚基) (层粘连蛋白-5 α亚基) (层粘连蛋白-6 α亚基) (层粘连蛋白-7 α亚基) (Nicein α亚基)

蛋白质信息 (UniProt)

层粘连蛋白α3亚基 (Epiligrin 170 kDa亚基) (E170) (Epiligrin α亚基) (Kalinin α亚基) (层粘连蛋白-5 α亚基) (层粘连蛋白-6 α亚基) (层粘连蛋白-7 α亚基) (Nicein α亚基)

Q16787

功能描述

通过高亲和力受体与细胞结合,laminin被认为通过与其他细胞外基质成分相互作用,在胚胎发育期间介导细胞附着、迁移和组织进入组织中;FUNCTION: Laminin-5被认为参与(1)通过灶性粘附中的整合素alpha-3/beta-1和半桥粒中的整合素alpha-6/beta-4进行的细胞粘附,(2)通过pp125-FAK和p80的酪氨酸磷酸化进行的信号转导,(3)角质形成细胞的分化。

组织特异性

Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.

亚细胞定位

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

关键词

Alternative splicing Basement membrane Cell adhesion Coiled coil Disease variant Disulfide bond Epidermolysis bullosa Extracellular matrix Glycoprotein Laminin EGF-like domain