KRT8 P05787

II型细胞骨架角蛋白8 (细胞角蛋白-8) (CK-8) (角蛋白-8) (K8) (II型角蛋白 Kb8)

蛋白质信息 (UniProt)

II型细胞骨架角蛋白8 (细胞角蛋白-8) (CK-8) (角蛋白-8) (K8) (II型角蛋白 Kb8)

P05787

功能描述

为KRT8/KRT18纤维的形成所必需，这些纤维参与ARHGEF40介导的肌动蛋白应力纤维形成以及张力诱导的应力纤维形成和加固 (PubMed:26823019)。与KRT19一起，有助于在横纹肌的肋节处将收缩装置与肌营养不良蛋白连接。 {ECO:0000269|PubMed:16000376, ECO:0000269|PubMed:26823019}。

组织特异性

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Alternative splicing Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Host-virus interaction

外部链接

UniProt: P05787

NCBI Gene

GeneCards