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KRT74 Q7RTS7

II型细胞骨架角蛋白74 (细胞角蛋白-74) (CK-74) (角蛋白-5c) (K5C) (角蛋白-74) (K74) (II型内根鞘特异性角蛋白-K6irs4) (II型角蛋白 Kb37)

蛋白质信息 (UniProt)

II型细胞骨架角蛋白74 (细胞角蛋白-74) (CK-74) (角蛋白-5c) (K5C) (角蛋白-74) (K74) (II型内根鞘特异性角蛋白-K6irs4) (II型角蛋白 Kb37)

Q7RTS7

功能描述

在毛发形成中发挥作用。毛囊内根鞘(IRS)角蛋白中间丝的特异性组分 (Probable)。 {ECO:0000305}。

组织特异性

Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level).

关键词

Coiled coil Disease variant Ectodermal dysplasia Hypotrichosis Intermediate filament Keratin Phosphoprotein Proteomics identification Reference proteome