KRT2 P35908

角蛋白，II型细胞骨架2表皮 (细胞角蛋白-2e) (CK-2e) (上皮角蛋白-2e) (角蛋白-2表皮) (角蛋白-2e) (K2e) (II型角蛋白Kb2)

功能描述

可能促进终末角质化 (PubMed:1380918)。与角质形成细胞的活化、增殖和角质化相关 (PubMed:12598329)。维持耳表皮基底上角质形成细胞中角质细胞和角蛋白丝所必需的，可能通过调节角蛋白及其伴侣蛋白的表达和定位来实现 (By similarity)。在足底皮肤表皮屏障的建立中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q3TTY5, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}。

组织特异性

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

亚细胞定位

Cytoplasm