KRT14 P02533

I型细胞角蛋白14 (细胞角蛋白-14) (CK-14) (角蛋白-14) (K14)

功能描述

非螺旋尾部结构域参与促进KRT5-KRT14纤维自组装成大束，并增强体外角蛋白中间纤维弹性相关的机械特性。 {ECO:0000269|PubMed:11724817}。

组织特异性

Expressed in the corneal epithelium (at protein level) (PubMed:26758872). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair (PubMed:9457912). Found in keratinocytes surrounding the club hair during telogen (PubMed:9457912).

亚细胞定位

Cytoplasm