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KRT10 P13645

I型细胞角蛋白10 (细胞角蛋白-10) (CK-10) (角蛋白-10) (K10)

蛋白质信息 (UniProt)

I型细胞角蛋白10 (细胞角蛋白-10) (CK-10) (角蛋白-10) (K10)

P13645

功能描述

在足底皮肤表皮屏障的建立中起作用 (By similarity)。参与上皮组织基底上细胞中细胞层发育和角蛋白丝束的维持 (By similarity)。 {ECO:0000250|UniProtKB:P02535}。; FUNCTION: (Microbial infection) 作为金黄色葡萄球菌通过clfB粘附于脱屑鼻上皮细胞的介导者,因此可能在鼻腔定植中起作用。 {ECO:0000269|PubMed:15385531}。; FUNCTION: (Microbial infection) 结合肺炎链球菌PsrP,介导细菌对肺细胞系的粘附。降低KRT10角蛋白水平会减少粘附,过表达则增加粘附。两种蛋白均无需糖基化即可发生相互作用。 {ECO:0000269|PubMed:19627498}。

组织特异性

Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Localized on the surface of desquamated nasal epithelial cells (at protein level) (PubMed:12427098).

亚细胞定位

Secreted, extracellular space

关键词

3D-structure Coiled coil Cytoplasm Direct protein sequencing Disease variant Disulfide bond Ichthyosis Intermediate filament Keratin Phosphoprotein