KNTC1 P50748

动粒相关蛋白1 (Rough deal同源物) (HsROD) (Rod) (hRod)

功能描述

有丝分裂检查点的重要组分，该检查点防止细胞过早退出有丝分裂。为动力蛋白-动力蛋白激活蛋白复合物和MAD1-MAD2复合物组装到动粒上所必需 (PubMed:11146660, PubMed:11590237, PubMed:15824131)。其与纺锤体组装机制相关的功能被认为取决于其在有丝分裂RZZ复合物中的结合。 {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}。

组织特异性

High expression in testis.

亚细胞定位

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.