组蛋白-赖氨酸N-甲基转移酶2C (赖氨酸N-甲基转移酶2C) (EC 2.1.1.364) (ALR蛋白同源物) (髓系/淋巴样或混合谱系白血病蛋白3)
组蛋白-赖氨酸N-甲基转移酶2C (赖氨酸N-甲基转移酶2C) (EC 2.1.1.364) (ALR蛋白同源物) (髓系/淋巴样或混合谱系白血病蛋白3)
Q8NEZ4功能描述
组蛋白甲基转移酶，催化甲基从S-adenosyl-L-methionine转移到组蛋白H3 (H3K4)的'Lys-4'的epsilon-氨基团上 (PubMed:25561738)。作为染色质重塑机制的一部分，主要在发生转录和DNA修复的活性染色质位点形成H3K4me1甲基化标记 (PubMed:22266653, PubMed:24081332, PubMed:25561738)。可能在富集预活化和活性增强子元件上的H3K4me1标记方面与KMT2D发挥冗余作用 (PubMed:24081332)。 {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}。
组织特异性
Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
亚细胞定位
Nucleus
关键词