杀伤细胞凝集素样受体亚家族F成员1 (凝集素样受体F1) (激活共受体NKp80) (C型凝集素结构域家族5成员C)
杀伤细胞凝集素样受体亚家族F成员1 (凝集素样受体F1) (激活共受体NKp80) (C型凝集素结构域家族5成员C)
Q9NZS2功能描述
作为一种激活受体发挥作用，在结合髓系细胞表面展示的各种配体后参与免疫监视。与CLEC2B配体相互作用后，刺激NK细胞细胞毒性和细胞因子产生，导致表达CLEC2B的恶性髓系细胞溶解。常见细胞毒性途径的激活涉及SRC和SYK激酶 (PubMed:21149606)。 {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:21149606}。
组织特异性
Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.
亚细胞定位
Membrane
关键词