激肽释放酶-8 (hK8) (EC 3.4.21.118) (神经蛋白酶) (NP) (Ovasin) (丝氨酸蛋白酶 19) (丝氨酸蛋白酶 TADG-14) (肿瘤相关差异表达基因14蛋白)
激肽释放酶-8 (hK8) (EC 3.4.21.118) (神经蛋白酶) (NP) (Ovasin) (丝氨酸蛋白酶 19) (丝氨酸蛋白酶 TADG-14) (肿瘤相关差异表达基因14蛋白)
O60259功能描述
丝氨酸蛋白酶，能够降解多种蛋白质，如酪蛋白、纤维蛋白原、激肽原、纤连蛋白和IV型胶原。也能响应神经活动的增强而切割L1CAM。诱导培养的海马神经元的神经突生长和成束。在Schaffer侧支通路中孤儿突触和小突触扣的形成和成熟中起作用，调节海马Schaffer侧支长时程增强，并且是记忆获取和突触可塑性所必需的。参与皮肤脱屑和角质形成细胞增殖。在脊髓损伤后的继发性发病机制阶段起作用。 {ECO:0000269|PubMed:16337200}。
组织特异性
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
亚细胞定位
Secreted
关键词