KLK7 P49862

激肽释放酶-7 (hK7) (EC 3.4.21.117) (丝氨酸蛋白酶 6) (角质层糜蛋白酶) (hSCCE)

功能描述

可能在皮肤表面细胞的持续脱落过程中，催化皮肤角质层细胞间粘附结构的降解。对P1位具有芳香侧链的氨基酸残基具有特异性。在'14-Tyr-|-Gln-15'处切割胰岛素A链，在'6-Leu-|-Cys-7'、'16-Tyr-|-Leu-17'、'25-Phe-|-Tyr-26'和'26-Tyr-|-Thr-27'处切割胰岛素B链。可能在炎症细胞因子前体的激活中发挥作用。 {ECO:0000269|PubMed:23370777}。

组织特异性

Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).

亚细胞定位

Secreted