KLF15 Q9UIH9

Krueppel样因子15 (肾富集Krueppel样因子)

功能描述

转录调节因子，结合CLCNKA启动子的GA元件。结合KCNIP2启动子并调节心脏中KCNIP2的节律性表达 (By similarity)。是CCN2表达的抑制因子，参与心脏纤维化的控制。它还通过抑制MEF2A和GATA4参与控制心肌肥大 (By similarity)。参与足细胞分化 (By similarity)。抑制MYOCD活性。是TP53乙酰化的负调节因子。通过抑制EP300依赖的RELA乙酰化来抑制NF-kappa-B激活。 {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}。

组织特异性

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.

亚细胞定位

Nucleus