KIN O60870

DNA/RNA结合蛋白KIN17 (结合弯曲DNA) (KIN, recA蛋白同源物抗原决定簇)

蛋白质信息 (UniProt)

DNA/RNA结合蛋白KIN17 (结合弯曲DNA) (KIN, recA蛋白同源物抗原决定簇)

O60870

功能描述

参与DNA复制和细胞对DNA损伤的反应。可能参与DNA复制工厂，并通过高分子量复合物在DNA复制和修复之间建立桥梁。可能在非正常重组和gene表达调控中发挥作用。可能参与mRNA加工。在体外结合双链DNA。亦显示在体外和体内优先结合弯曲DNA（通过相似性）。在体外通过其C末端结构域结合RNA。 {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}。

组织特异性

Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level).

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Coiled coil Cytoplasm Direct protein sequencing DNA damage DNA recombination DNA repair DNA replication DNA-binding

外部链接

UniProt: O60870

NCBI Gene

GeneCards