驱动蛋白样蛋白 KIF1B (Klp) (EC 5.6.1.3)
驱动蛋白样蛋白 KIF1B (Klp) (EC 5.6.1.3)
O60333功能描述
具有正向导向的微管马达活性，并作为马达蛋白沿微管运输囊泡和细胞器。 {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: 具有正向导向的微管马达活性，并在神经细胞中作为马达蛋白沿轴突微管从细胞体向突触前膜进行顺行性突触囊泡运输 (By similarity)。作为发育凋亡途径中的下游效应因子，当神经生长因子 (NGF) 对神经前体细胞变得有限时该途径被激活 (PubMed:18334619)。 {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: 具有正向导向的微管马达活性，并作为马达蛋白进行线粒体的顺行性运输。 {ECO:0000269|PubMed:16225668}.
组织特异性
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
亚细胞定位
Cytoplasm, cytoskeleton
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