钾电压门控通道KQT亚家族成员2 (KQT样2) (神经母细胞瘤特异性钾通道亚基α KvLQT2) (电压门控钾通道亚基Kv7.2)
钾电压门控通道KQT亚家族成员2 (KQT样2) (神经母细胞瘤特异性钾通道亚基α KvLQT2) (电压门控钾通道亚基Kv7.2)
O43526功能描述
电压门控钾(Kv) M通道的成孔亚基，该通道负责M电流，是神经元兴奋性的关键调控因子 (PubMed:24277843, PubMed:28793216, PubMed:9836639)。M通道由成孔亚基KCNQ2和KCNQ3组装成异源四聚体 (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639)。天然的M电流具有缓慢激活和去激活的钾电导，在决定神经元的阈下电兴奋性以及对突触输入的反应性方面起着关键作用 (PubMed:14534157, PubMed:28793216, PubMed:9836639)。KCNQ2-KCNQ3 M通道在体外对除钾以外的其他阳离子具有选择性通透性，亲和力依次降低为 K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216)。M通道与SLC5A3/SMIT1结合会改变通道的离子选择性，增加Na(+)和Cs(+)相对于K(+)的通透性 (PubMed:28793216)。受毒蕈碱型乙酰胆碱受体CHRM1激活的抑制 (PubMed:10684873, PubMed:10713961)。 {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}。
组织特异性
In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal cord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.
亚细胞定位
Cell membrane
关键词