钙激活钾通道β4亚基 (BK通道β4亚基) (BKbeta4) (Hbeta4) (钙激活钾通道M亚家族β4亚基) (蝎毒素受体β4亚基) (K(VCA)beta-4) (Maxi K通道β4亚基) (Slo-beta-4)
钙激活钾通道β4亚基 (BK通道β4亚基) (BKbeta4) (Hbeta4) (钙激活钾通道M亚家族β4亚基) (蝎毒素受体β4亚基) (K(VCA)beta-4) (Maxi K通道β4亚基) (Slo-beta-4)
Q86W47功能描述
钙激活钾通道KCNMA1 (maxiK)的调节亚基。调节KCNMA1的钙敏感性和门控动力学,从而有助于KCNMA1通道的多样性。降低KCNMA1通道的门控动力学和钙敏感性,但具有快速失活动力学。可能在低钙浓度下减少KCNMA1通道开放,但在高钙浓度下增加通道开放。使KCNMA1通道对100 nM charybdotoxin (CTX)毒素浓度产生抗性。 {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}。
组织特异性
Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
亚细胞定位
Membrane; Multi-pass membrane protein.
关键词